• home
• research
• Coffee, Decaffeinated Coffee, Tea Intake, and Risk of Renal Cell Cancer

Coffee, Decaffeinated Coffee, Tea Intake, and Risk of Renal Cell Cancer

• Posted: 24 September 2009
• Categroy: Independent Research

Maurizio Montella; Irene Tramacere; Alessandra Tavani; Silvano Gallus; Anna Crispo; Renato Talamini; Luigino Dal Maso; Valerio Ramazzotti; Carlotta Galeone; Silvia Franceschi; Carlo La Vecchia

Abstract:

The relation between coffee, decaffeinated coffee, and tea intake and renal cell
carcinoma (RCC) risk was analyzed in a case-control study conducted in Italy
between 1992 and 2004. Cases were 767 subjects with incident histologically
confirmed RCC and controls were 1,534 patients in hospital for acute non
neoplastic conditions. Odds ratios (OR) and 95% confidence intervals (CI) for
RCC were computed by multiple logistic regression models, conditioned on study
center, sex, and age. Coffee intake (mostly espresso and mocha) was not
associated with RCC risk, with an OR of 1.02 (95% CI 0.73-1.43) in drinkers of ≥ 4 cups/day compared with drinkers of < 1 cup/day. The corresponding ORs were
1.34 (95% CI 0.87-2.07) in men and 0.67 (95% CI 0.38-1.18) in women, 1.91 (95% CI 0.85-4.31) in current smokers and 0.74 (95% CI 0.41-1.31) in never smokers, with no trend in risk with dose. No relation was observed with decaffeinated coffee (OR = 1.38, 95% CI 0.94-2.03 for drinkers compared with nondrinkers) and tea intake (OR = 0.78, 95% CI 0.59-1.05 for drinkers of ≥ 1 cup/day compared with nondrinkers). No significant heterogeneity was found for coffee intake across strata of age, education, body mass index, and consumption of sugar. This study, based on a large dataset, provides further evidence that coffee, decaffeinated coffee, and tea consumption are not related to RCC risk.

Research